tlr

Description: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include MyD88, TIRAP, TIRP, TOLLIP, and TRIF. These molecules interact with and activate the IL-1R-associated kinase (IRAK) family, which then activates TNF receptor associated factor (TRAF)-6, and ultimately leads to the activation of NF-κB. While most TLRs utilize more than one adaptor, certain adaptor molecules are essential for individual TLR signaling, e.g., TLR4 signaling is dependent on TIRP expression.;;For images please see PDF data sheet

Description: TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

Description: TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.0 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

Description: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include MyD88, TIRAP, TIRP, TOLLIP, and TRIF. These molecules interact with and activate the IL-1R-associated kinase (IRAK) family, which then activates TNF receptor associated factor (TRAF)-6, and ultimately leads to the activation of NF-κB. While most TLRs utilize more than one adaptor, certain adaptor molecules are essential for individual TLR signaling, e.g., TLR4 signaling is dependent on TIRP expression.;;For images please see PDF data sheet

Description: TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.4 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

Description: A Monoclonal antibody against Human TLR-1 (extracellular). The antibodies are raised in Rabbit and are from clone EPR2075. This antibody is applicable in WB

Description: A Monoclonal antibody against Human TLR-2 (extracellular). The antibodies are raised in Rabbit and are from clone EPR2078Y. This antibody is applicable in WB

Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Description: Quantitativesandwich ELISA kit for measuring Mouse Toll-like receptor 5, TLR-5 in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Mouse Toll-like receptor 5, TLR-5 in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Description: Quantitativesandwich ELISA kit for measuring Mouse Toll-like receptor 7, TLR-7 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Mouse Toll-like receptor 7, TLR-7 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Description: Quantitativesandwich ELISA kit for measuring Human toll-like receptor 7, TLR-7 in samples from serum, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Human toll-like receptor 7, TLR-7 in samples from serum, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Description: Quantitativesandwich ELISA kit for measuring Rat Toll-like receptor 9, TLR-9 in samples from serum, plasma. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Rat Toll-like receptor 9, TLR-9 in samples from serum, plasma. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Description: Quantitativesandwich ELISA kit for measuring Human Toll-like receptor 9, TLR-9 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Human Toll-like receptor 9, TLR-9 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol.

Description: The substance Cyclopamine is a hedgehog signaling blocker. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 5 mM in ethanol.

Description: A sandwich ELISA kit for quantitative measurement of Rat TLR-2 (Toll-like Receptor 2) in samples from Serum, Plasma, Cell supernatant

Description: Quantitative sandwich ELISA for measuring Mouse Toll-like receptor 5 (TLR-5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Mouse Toll-like receptor 5 (TLR-5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Mouse Toll-like receptor 5 (TLR-5) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: A sandwich CLIA kit for quantitative measurement of Rat TLR-2 (Toll-Like Receptor 2) in samples from Serum, Plasma, Cell supernatant

Description: A sandwich ELISA kit for quantitative measurement of Human TLR-2 (Toll-like Receptor 2) in samples from Serum, Plasma, Cell supernatant

Description: Quantitative sandwich ELISA for measuring Human Toll-like receptor 7 (TLR-7) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Toll-like receptor 7 (TLR-7) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Toll-like receptor 7 (TLR-7) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Toll-like receptor 7 (TLR-7) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Toll-like receptor 7 (TLR-7) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Toll-like receptor 7 (TLR-7) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.