The choline-acetylcholine cycle. The enzyme choline acetyltransferase builds acetylcholine (ACH) from choline (CHO) and acetyl-CoA. After ACH is released in the synaptic cleft, the enzyme acetylcholinesterase converts ACH into the inactive metabolites CHO and acetate. After re-uptake into the pre-synaptic terminal, free CHO is phosphorylated into phosphocholine (PHC), a reaction catalysed by choline kinase. PHC …

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