Why over-expression of both p63 and p73 induces apoptosis and modulates p53 target genes?

This is observed in a lot of cell types (Moll et al., 2001).

Although it will be possible that this activity merely reflects the ability of protein to have p53 works when sufficiently over-expressed, rising evidence shows that p63 and p73 might be triggered in a reaction to selected apoptotic causes, for example DNA damage, over-expression of E2F1 or activated oncogenes (Katoh et al., 2000; Soengas and Lowe, 2000).

What’s more, the trans-activation domain-deficient isoforms of p63 and p73 are overexpressed in some human tumors (see, for inspection, Moll et al., 2001; Melino et al., 2002; Benard et al., 2003), at which they can act as dominant negatives or interfere with normal p53 function by forming amalgamated complexes with p53 (Moll et al., 2001).

Additionally, a few missense p53 mutants bind p73 and interfere with chemotherapy-induced apoptosis (Bergamaschi et al., 2003; Irwin et al., 2003). These effects may reveal a few p53 mutants’ gain-of-function routines and establish that a mechanism of chemoresistance.

Even though p53 stimulates apoptosis by intricate mechanisms, we centered on the mitochondria, as others, along with our group, scientists established that air borne exposures that cause lung cancer–as an instance, PM and debris, but maybe not inert particulates (e.g., glass rings or ceramic dioxide)–induce apoptosis by triggering the mitochondria-dependent passing pathway (9, 10, 28). We also notice minimal levels of caspase-8 (the death receptor triggered caspase) within our procedure after exposure to either PM or debris.

Antibodies use for apoptosis research are cited here under:

Cat	Name	Size	Price
E13-025-2	p53	50μg	570.00 EUR
4-RPA928Hu02	Recombinant Tumor Protein p53 (P53)	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg	565.92 EUR 254.00 EUR 1847.20 EUR 682.40 EUR 1264.80 EUR 442.00 EUR 4468.00 EUR
4-RPA928Hu03	Recombinant Tumor Protein p53 (P53)	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg	565.92 EUR 254.00 EUR 1847.20 EUR 682.40 EUR 1264.80 EUR 442.00 EUR 4468.00 EUR
20-abx008609	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx008610	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx008611	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx008612	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx008613	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx008614	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx009877	p53 Phospho-Ser15 (p53 pS15) Antibody	100 ul 200 ul 30 ul	314.00 EUR 467.00 EUR 203.00 EUR
abx018341-100ug	Cellular Tumor Antigen P53 (P53) Antibody	100 ug	453.00 EUR
abx019148-100ug	Cellular Tumor Antigen P53 (P53) Antibody	100 ug	342.00 EUR
abx020578-02mg	Cellular Tumor Antigen P53 (p53) Antibody	0.2 mg	467.00 EUR
20-abx121795	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
abx037925-100ug	Cellular Tumor Antigen P53 (p53) Antibody	100 ug	391.00 EUR
20-abx133358	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx134518	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx134519	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	300.00 EUR 439.00 EUR 189.00 EUR
20-abx134520	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	356.00 EUR 537.00 EUR 217.00 EUR
20-abx134521	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	356.00 EUR 537.00 EUR 217.00 EUR
20-abx137175	Cellular Tumor Antigen P53 (p53) Antibody	0.2 mg 0.5 mg 100 ug	871.00 EUR 1720.00 EUR 551.00 EUR
abx139924-01mg	Cellular Tumor Antigen P53 (p53) Antibody	0.1 mg	370.00 EUR
20-abx141063	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	356.00 EUR 537.00 EUR 217.00 EUR
20-abx141064	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	356.00 EUR 537.00 EUR 217.00 EUR
20-abx141088	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	356.00 EUR 537.00 EUR 217.00 EUR
20-abx141162	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	356.00 EUR 537.00 EUR 217.00 EUR
20-abx141164	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	356.00 EUR 537.00 EUR 217.00 EUR
20-abx141175	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 30 ul	384.00 EUR 606.00 EUR 230.00 EUR
20-abx142273	Cellular Tumor Antigen P53 (p53) Antibody	100 ul 200 ul 50 ul	370.00 EUR 606.00 EUR 314.00 EUR
abx011309-100ul	Cellular Tumor Antigen P53 (p53) Antibody	100 ul	411.00 EUR
abx012305-100ug	p53 Phospho-Ser15 (p53 pS15) Antibody	100 ug	439.00 EUR
20-abx013359	Cellular Tumor Antigen P53 (p53) Antibody	100 ug 10 ug 200 ug 300 µg	314.00 EUR 98.00 EUR 398.00 EUR 495.00 EUR
abx032760-400ul	Cellular Tumor Antigen P53 (p53) Antibody	400 ul	523.00 EUR
abx032760-80l	Cellular Tumor Antigen P53 (p53) Antibody	80 µl	286.00 EUR
abx032761-400ul	Cellular Tumor Antigen P53 (p53) Antibody	400 ul	523.00 EUR
abx032761-80l	Cellular Tumor Antigen P53 (p53) Antibody	80 µl	286.00 EUR
abx032762-400ul	Cellular Tumor Antigen P53 (p53) Antibody	400 ul	523.00 EUR
abx032762-80l	Cellular Tumor Antigen P53 (p53) Antibody	80 µl	286.00 EUR
abx032763-400ul	Cellular Tumor Antigen P53 (p53) Antibody	400 ul	523.00 EUR
abx032763-80l	Cellular Tumor Antigen P53 (p53) Antibody	80 µl	286.00 EUR
abx413267-01mg	Cellular Tumor Antigen P53 (p53) Antibody	0.1 mg	439.00 EUR
abx413271-01mg	Cellular Tumor Antigen P53 (p53) Antibody	0.1 mg	439.00 EUR
abx413272-01mg	Cellular Tumor Antigen P53 (p53) Antibody	0.1 mg	439.00 EUR
abx236083-100ug	Cellular Tumor Antigen P53 (P53) Antibody	100 ug	481.00 EUR
abx236084-100ug	Cellular Tumor Antigen P53 (P53) Antibody	100 ug	551.00 EUR
abx448535-100ug	Cellular Tumor Antigen P53 (p53) Antibody	100 ug	523.00 EUR
abx444908-100ug	Cellular Tumor Antigen P53 (p53) Antibody	100 ug	453.00 EUR
20-abx000156	p53 Phospho-Ser15 (p53 pS15) Antibody	100 ul 200 ul 20 ul 50 ul	495.00 EUR 704.00 EUR 217.00 EUR 356.00 EUR
3036R-100	p53 Antibody		316.00 EUR
3036R-30T	p53 Antibody		146.00 EUR
30R-3131	p53 protein	50 ug	257.00 EUR
30R-3187	p53 protein	50 ug	257.00 EUR
20R-1436	p53 antibody	100 ug	673.00 EUR
20R-1619	p53 antibody	100 ug	813.00 EUR
20R-1950	p53 antibody	50 ug	281.00 EUR
20R-1951	p53 antibody	50 ug	281.00 EUR
20R-1952	p53 antibody	50 ug	281.00 EUR
20R-1954	p53 antibody	50 ug	281.00 EUR
20R-1955	p53 antibody	50 ug	281.00 EUR
20R-1956	p53 antibody	50 ug	281.00 EUR
20R-1957	p53 antibody	50 ug	281.00 EUR
20R-2264	p53 antibody	50 ug	281.00 EUR
20R-2265	p53 antibody	50 ug	281.00 EUR
20R-2266	p53 antibody	50 ug	281.00 EUR
20R-2267	p53 antibody	50 ug	281.00 EUR
20R-2268	p53 antibody	50 ug	281.00 EUR
20R-2269	p53 antibody	50 ug	281.00 EUR
20R-2270	p53 antibody	50 ug	281.00 EUR
20R-2271	p53 antibody	50 ug	281.00 EUR
20R-2904	p53 antibody	100 ul	393.00 EUR
70R-11573	p53 antibody	100 ug	403.00 EUR
70R-31561	p53 antibody	100 ug	327.00 EUR
70R-15485	p53 antibody	100 ug	327.00 EUR
33650-100ul	p53 Antibody	100ul	252.00 EUR
33650-50ul	p53 Antibody	50ul	187.00 EUR
10R-1910	p53 antibody	100 ul	403.00 EUR
10R-2361	p53 antibody	2 x 25 ug	359.00 EUR
10R-2391	p53 antibody	5 mL	265.00 EUR
10R-P159A	p53 antibody	100 ug	543.00 EUR
10R-P160A	p53 antibody	100 ug	457.00 EUR
10R-10381	P53 antibody	100 ug	435.00 EUR
10-2559	p53 antibody	250 ug	492.00 EUR
10-2560	p53 antibody	250 ug	492.00 EUR
10-2561	p53 antibody	250 ug	492.00 EUR
10-2562	p53 antibody	250 ug	492.00 EUR
10R-6721	p53 antibody	100 ug	651.00 EUR
10R-6772	p53 antibody	1 ml	402.00 EUR
10R-7889	p53 antibody	100 ug	305.00 EUR
10R-8113	p53 antibody	100 ug	435.00 EUR
10R-8591	p53 antibody	100 ul	393.00 EUR
48599-100ul	p53 Antibody	100ul	333.00 EUR
48599-50ul	p53 Antibody	50ul	239.00 EUR
48719-100ul	p53 Antibody	100ul	333.00 EUR
48719-50ul	p53 Antibody	50ul	239.00 EUR
DB-002-0.05	Anti-p53	50 μl	302.00 EUR
DB-002-0.1	Anti-p53	100 μl	477.00 EUR
DB-026-0.1	Anti-p53	100 μl	204.00 EUR
DB-026-0.2	Anti-p53	200 μl	286.00 EUR
DB-026-0.5	Anti-p53	500 μl	368.00 EUR
DB-026-1	Anti-p53	1 ml	586.00 EUR
DB-026-RTU-15	Anti-p53	15 ml	338.00 EUR
DB-026-RTU-7	Anti-p53	7 ml	222.00 EUR
DB-1012	Anti-p53	100 tests	452.00 EUR
DB026RTU-15	Anti-p53	15 ml	338.00 EUR
DB026RTU-7	Anti-p53	7 ml	222.00 EUR
DB1012	Anti-p53	100 tests	452.00 EUR
DF6066	p53 Antibody	200ul	304.00 EUR
70R-35291	p53 antibody	100 ug	327.00 EUR
70R-36652	p53 antibody	100 ug	327.00 EUR
70R-37523	p53 antibody	100 ug	273.00 EUR
70R-37524	p53 antibody	100 ug	273.00 EUR
70R-37525	p53 antibody	100 ug	273.00 EUR
70R-37526	p53 antibody	100 ug	273.00 EUR
70R-37528	p53 antibody	100 ug	273.00 EUR
70R-37529	p53 antibody	100 ug	273.00 EUR
70R-37530	p53 antibody	100 ug	273.00 EUR
70R-37531	p53 antibody	100 ug	273.00 EUR
70R-50503	p53 antibody	100 ul	287.00 EUR
70R-50504	p53 antibody	100 ul	287.00 EUR
70R-50505	p53 antibody	100 ul	244.00 EUR
70R-50506	p53 antibody	100 ul	244.00 EUR
70R-50507	p53 antibody	100 ul	244.00 EUR
70R-50508	p53 antibody	100 ul	244.00 EUR
70R-50509	p53 antibody	100 ul	244.00 EUR
70R-50510	p53 antibody	100 ul	244.00 EUR
70R-51663	p53 antibody	100 ul	287.00 EUR
70R-51664	p53 antibody	100 ul	287.00 EUR
70R-51665	p53 antibody	100 ul	244.00 EUR
70R-51666	p53 antibody	100 ul	244.00 EUR
70R-34329	p53 antibody	100 ug	327.00 EUR
70R-34331	p53 antibody	100 ug	327.00 EUR
70R-34333	p53 antibody	100 ug	327.00 EUR
70R-34335	p53 antibody	100 ug	327.00 EUR
70R-34337	p53 antibody	100 ug	327.00 EUR
70R-34339	p53 antibody	100 ug	327.00 EUR
70R-34341	p53 antibody	100 ug	327.00 EUR
70R-34343	p53 antibody	100 ug	327.00 EUR
20-abx137497	p53 Antibody	10 ug 1 mg 2 µg	328.00 EUR 6675.00 EUR 230.00 EUR
20-abx263531	p53 Protein	10 ug 2 µg 5 ug	829.00 EUR 411.00 EUR 537.00 EUR
AF0865	p53 Antibody	200ul	304.00 EUR
AF0877	p53 Antibody	200ul	304.00 EUR
AF0879	p53 Antibody	200ul	304.00 EUR
AF4663	p53 Antibody	200ul	376.00 EUR
AF4664	p53 Antibody	200ul	376.00 EUR
AF6073	p53 Antibody	200ul	304.00 EUR
AF6074	p53 Antibody	200ul	304.00 EUR
AF6078	P53 Antibody	200ul	304.00 EUR
BF0604	p53 Antibody	200ul	376.00 EUR
AF7685	p53 Antibody	200ul	376.00 EUR
AF7686	p53 Antibody	200ul	376.00 EUR

p53 mediated Apoptosis

p53 Antibody
ABF6073	Lifescience Market	100 ug
p53 Antibody
ABD6066	Lifescience Market	100 ug
p53 Antibody
ABF0865	Lifescience Market	100 ug
p53 Antibody
ABF0877	Lifescience Market	100 ug
p53 Antibody
ABF0879	Lifescience Market	100 ug
anti-p53
LF-PA0050	Abfrontier	100 ul
p53 Antibody
P1022-01m	SAB	0.1m
p53 Antibody
P1022-1ml	SAB	1ml
p53- Luc
PVT10836	Lifescience Market	2 ug
p53- His2
PVT11251	Lifescience Market	2 ug
P53- GFP
PVT11397	Lifescience Market	2 ug
anti-p53
YF-PA15085	Abfrontier	50 ug
anti-p53
YF-PA15087	Abfrontier	50 ug
anti-p53
YF-PA15088	Abfrontier	100 ul
anti-p53
YF-PA15089	Abfrontier	100 ug
anti-p53
YF-PA15090	Abfrontier	100 ug
anti-p53
YF-PA24879	Abfrontier	50 ul
Human Acetylated p53(Acetylated p53) ELISA Kit
EH4216	FN Test	96T
p53/TP53/ Rat p53/ TP53 ELISA Kit
ELA-E0928r	Lifescience Market	96 Tests
Cellular Tumor Antigen P53 (p53) Antibody (Biotin)
abx413268-01mg	Abbexa	0.1 mg
Cellular Tumor Antigen P53 (p53) Antibody (FITC)
abx413269-01mg	Abbexa	0.1 mg
Cellular Tumor Antigen P53 (p53) Antibody (RPE)
abx413270-100tests	Abbexa	100 tests
Cellular Tumor Antigen P53 (p53) Antibody (ALP)
abx442310-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (APC)
abx442591-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (Biotin)
abx442872-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (FITC)
abx443152-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (HRP)
abx443432-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (PerCP)
abx443994-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (RPE)
abx444275-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (Streptavidin)
abx444556-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ALP)
abx446373-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (APC)
abx446374-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (PerCP)
abx446379-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (RPE)
abx446380-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (Streptavidin)
abx446381-100ug	Abbexa	100 ug
Human Acetylated p53 & Total p53 ELISA Kit
QY-E05440	Qayee Biotechnology	96T
Human p53/tumor protein,p53/TP53 ELISA Kit
201-12-1712	SunredBio	96 tests
Human p53 Phospho-Ser15 (p53 pS15) ELISA Kit
abx257458-96tests	Abbexa	96 tests
Human Total P53(Tumor Protein p53) ELISA Kit
EH3898	FN Test	96T
Rabbit p53/tumor protein,p53/TP53 ELISA Kit
CN-00573R1	ChemNorm	96T
Rabbit p53/tumor protein,p53/TP53 ELISA Kit
CN-00573R2	ChemNorm	48T
Human p53/tumor protein, p53/TP53 ELISA Kit
CSB-E08334h-24T	Cusabio	1 plate of 24 wells
Human p53/tumor protein, p53/TP53 ELISA Kit
1-CSB-E08334h	Cusabio	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Rat p53/tumor protein, p53/TP53 ELISA Kit
CSB-E08336r-24T	Cusabio	1 plate of 24 wells
Rat p53/tumor protein, p53/TP53 ELISA Kit
1-CSB-E08336r	Cusabio	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Mouse p53/tumor protein,p53/TP53 ELISA Kit
CN-02303M1	ChemNorm	96T
Mouse p53/tumor protein,p53/TP53 ELISA Kit
CN-02303M2	ChemNorm	48T
Human p53/tumor protein,p53/TP53 ELISA Kit
CN-03353H1	ChemNorm	96T
Human p53/tumor protein,p53/TP53 ELISA Kit
CN-03353H2	ChemNorm	48T
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 390)
abx440062-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 488)
abx440343-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 565)
abx440624-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 594)
abx440905-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 633)
abx441186-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 655)
abx441467-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 680)
abx441748-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 700)
abx442029-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 390)
abx446365-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 488)
abx446366-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 565)
abx446367-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 594)
abx446368-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 633)
abx446369-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 655)
abx446370-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 680)
abx446371-100ug	Abbexa	100 ug
Cellular Tumor Antigen P53 (p53) Antibody (ATTO 700)
abx446372-100ug	Abbexa	100 ug
Human p53/tumor protein(p53/TP53)ELISA Kit
GA-E1728HM-48T	GenAsia Biotech	48T
Human p53/tumor protein(p53/TP53)ELISA Kit
GA-E1728HM-96T	GenAsia Biotech	96T
Mouse p53/tumor protein(p53/TP53)ELISA Kit
GA-E0422MS-48T	GenAsia Biotech	48T
Mouse p53/tumor protein(p53/TP53)ELISA Kit
GA-E0422MS-96T	GenAsia Biotech	96T
Rabbit p53/tumor protein,p53/TP53 ELISA Kit
GA-E0162RB-48T	GenAsia Biotech	48T
Rabbit p53/tumor protein,p53/TP53 ELISA Kit
GA-E0162RB-96T	GenAsia Biotech	96T
Rat p53/tumor protein(p53/TP53)ELISA Kit
GA-E0080RT-48T	GenAsia Biotech	48T
Rat p53/tumor protein(p53/TP53)ELISA Kit
GA-E0080RT-96T	GenAsia Biotech	96T
Human p53/tumor protein(p53/TP53)ELISA Kit
QY-E04715	Qayee Biotechnology	96T
Human Phospho ser15 P53 & Total p53 ELISA Kit
QY-E05441	Qayee Biotechnology	96T
Rat p53/tumor protein(p53/TP53)ELISA Kit
QY-E11573	Qayee Biotechnology	96T
Mouse p53/tumor protein(p53/TP53)ELISA Kit
QY-E21135	Qayee Biotechnology	96T
Rabbit p53/tumor protein,p53/TP53 ELISA Kit
QY-E30138	Qayee Biotechnology	96T
p53 Blocking Peptide
3036RBP-50	Biovision
P53 Monoclonal Antibody
27021-100ul	SAB	100ul
P53 Monoclonal Antibody
27021-50ul	SAB	50ul
Phospho-p53 antibody
70R-11881	Fitzgerald	100 ug
Recombinant Human p53
7-05785	CHI Scientific	2µg
Recombinant Human p53
7-05786	CHI Scientific	5µg
Recombinant Human p53
7-05787	CHI Scientific	10µg
p53 antibody (Thr81)
70R-31503	Fitzgerald	100 ug
p53 Mouse mAb
A10610-100ul	Abclonal	100 ul
p53 Mouse mAb
A10610-200ul	Abclonal	200 ul
p53 Mouse mAb
A10610-20ul	Abclonal	20 ul
p53 Mouse mAb
A10610-50ul	Abclonal	50 ul
p53 Rabbit mAb
A11012-100ul	Abclonal	100 ul
p53 Rabbit mAb
A11012-200ul	Abclonal	200 ul
p53 Rabbit mAb
A11012-20ul	Abclonal	20 ul
p53 Rabbit mAb
A11012-50ul	Abclonal	50 ul
p53 Blocking Peptide
33R-10444	Fitzgerald	50 ug
p53 Blocking Peptide
33R-10604	Fitzgerald	50 ug
Phospho-p53 Antibody
3515-100	Biovision
Anti-p53 Purified
11-114-C025	ExBio	0.025 mg
Anti-p53 Purified
11-114-C100	ExBio	0.1 mg
Anti-p53 FITC
1F-114-C025	ExBio	0.025 mg
Anti-p53 FITC
1F-114-C100	ExBio	0.1 mg
p53 antibody (HRP)
60R-2272	Fitzgerald	100 ug
p53 antibody (FITC)
60R-2273	Fitzgerald	100 ug
p53 antibody (biotin)
60R-2274	Fitzgerald	100 ug
p53 antibody (FITC)
61R-1897	Fitzgerald	1 ml
Mutant p53 Antibody
49815-100ul	SAB	100ul
Mutant p53 Antibody
49815-50ul	SAB	50ul
p53 DINP1 Antibody
49906-100ul	SAB	100ul
p53 DINP1 Antibody
49906-50ul	SAB	50ul
p53 Polyclonal Antibody
41307-100ul	SAB	100ul
p53 Polyclonal Antibody
41307-50ul	SAB	50ul
p53 Polyclonal Antibody
41308-100ul	SAB	100ul
p53 Polyclonal Antibody
41308-50ul	SAB	50ul
p53 Polyclonal Antibody
41309-100ul	SAB	100ul
p53 Polyclonal Antibody
41309-50ul	SAB	50ul
p53 Polyclonal Antibody
41310-100ul	SAB	100ul
p53 Polyclonal Antibody
41310-50ul	SAB	50ul
p53 Polyclonal Antibody
41311-100ul	SAB	100ul
p53 Polyclonal Antibody
41311-50ul	SAB	50ul
p53 Polyclonal Antibody
41312-100ul	SAB	100ul
p53 Polyclonal Antibody
41312-50ul	SAB	50ul
p53 Polyclonal Antibody
41313-100ul	SAB	100ul
p53 Polyclonal Antibody
41313-50ul	SAB	50ul
p53 Polyclonal Antibody
41734-100ul	SAB	100ul
p53 Polyclonal Antibody
41734-50ul	SAB	50ul
p53 Polyclonal Antibody
41875-100ul	SAB	100ul
p53 Polyclonal Antibody
41875-50ul	SAB	50ul
p53 Polyclonal Antibody
41876-100ul	SAB	100ul
p53 Polyclonal Antibody
41876-50ul	SAB	50ul
Polyclonal p53 Antibody
APR00006G	Leading Biology	0.1mg
p53 Blocking Peptide
DF6066-BP	Affbiotech	1mg
p53 Rabbit pAb
A0263-100ul	Abclonal	100 ul
p53 Rabbit pAb
A0263-200ul	Abclonal	200 ul
p53 Rabbit pAb
A0263-20ul	Abclonal	20 ul
p53 Rabbit pAb
A0263-50ul	Abclonal	50 ul
p53 antibody (Ser392)
70R-35009	Fitzgerald	100 ug
p53 antibody (Ser20)
70R-35201	Fitzgerald	100 ug
p53 antibody (Ser6)
70R-37173	Fitzgerald	100 ug
p53 antibody (Ser15)
70R-37174	Fitzgerald	100 ug
p53 antibody (Thr18)
70R-37175	Fitzgerald	100 ug
p53 antibody (Ser33)
70R-37177	Fitzgerald	100 ug
p53 antibody (Ser37)
70R-37178	Fitzgerald	100 ug
p53 antibody (Ser46)
70R-37179	Fitzgerald	100 ug
p53 antibody (Ser315)
70R-37180	Fitzgerald	100 ug
P53 antibody (Ser20)
70R-37414	Fitzgerald	100 ug
P53 antibody (Ser37)
70R-37415	Fitzgerald	100 ug
p53 antibody (Thr387)
70R-32611	Fitzgerald	100 ug
p53 antibody (Ser376)
70R-32612	Fitzgerald	100 ug
p53 antibody (Ser366)
70R-32613	Fitzgerald	100 ug
p53 antibody (Ser378)
70R-32614	Fitzgerald	100 ug
p53 antibody (Ser15)
70R-34328	Fitzgerald	100 ug
p53 antibody (Ser315)
70R-34330	Fitzgerald	100 ug
p53 antibody (Ser33)
70R-34332	Fitzgerald	100 ug
p53 antibody (Ser37)
70R-34334	Fitzgerald	100 ug
p53 antibody (Ser46)
70R-34336	Fitzgerald	100 ug
p53 antibody (Ser6)
70R-34338	Fitzgerald	100 ug
p53 antibody (Ser9)
70R-34340	Fitzgerald	100 ug
p53 antibody (Thr18)
70R-34342	Fitzgerald	100 ug
p53 (pS315) Antibody
20-abx009876	Abbexa	100 ul 200 ul 30 ul
p53 (pT55) Antibody
abx219057-100ug	Abbexa	100 ug
p53 (pS392) Antibody
abx219058-100ug	Abbexa	100 ug
p53 (pT18) Antibody
20-abx119197	Abbexa	100 ug 10 ug 200 ug 300 µg
p53 (pS33) Antibody
20-abx119530	Abbexa	100 ug 10 ug 200 ug 300 µg
p53 (pS37) Antibody
20-abx119531	Abbexa	100 ug 10 ug 200 ug 300 µg
p53 (pS6) Antibody
20-abx119532	Abbexa	100 ug 10 ug 200 ug 300 µg
p53 (AcK386) Antibody
20-abx121192	Abbexa	100 ul 200 ul 30 ul
p53 (pS392) Antibody
20-abx121792	Abbexa	100 ul 200 ul 30 ul
p53 (AcK319) Antibody
20-abx121793	Abbexa	100 ul 200 ul 30 ul
p53 (AcK381) Antibody
20-abx121794	Abbexa	100 ul 200 ul 30 ul
P53 AIP1 Antibody
abx037562-100ug	Abbexa	100 ug
Human P53 Protein
20-abx060205	Abbexa	100 ug 1 mg 2.5 mg 2 mg
p53 (pS6) Antibody
20-abx133354	Abbexa	100 ul 200 ul 30 ul
p53 (pS9) Antibody
20-abx133355	Abbexa	100 ul 200 ul 30 ul
p53 (pT18) Antibody
20-abx133356	Abbexa	100 ul 200 ul 30 ul
p53 (pS20) Antibody
20-abx133357	Abbexa	100 ul 200 ul 30 ul
p53 (pS33) Antibody
20-abx134516	Abbexa	100 ul 200 ul 30 ul
p53 (pS37) Antibody
20-abx134517	Abbexa	100 ul 200 ul 30 ul
p53 Blocking Peptide
20-abx161505	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx162067	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx162208	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx162209	Abbexa	1 mg 5 mg
p53 (pS392) Antibody
abx139925-01mg	Abbexa	0.1 mg
p53 Antibody (FITC)
abx139926-01mg	Abbexa	0.1 mg
p53 (pS46) Antibody
20-abx141020	Abbexa	100 ul 200 ul 30 ul
p53 (AcK370) Antibody
20-abx141163	Abbexa	100 ul 200 ul 30 ul
p53 (AcK382) Antibody
20-abx141165	Abbexa	100 ul 200 ul 30 ul
p53 (pS46) Antibody
abx012295-100ug	Abbexa	100 ug
p53 (pS20) Antibody
abx012297-100ug	Abbexa	100 ug
p53 (pS9) Antibody
abx012298-100ug	Abbexa	100 ug
p53 (pS366) Antibody
abx012299-100ug	Abbexa	100 ug
p53 (pS392) Antibody
abx012300-100ug	Abbexa	100 ug
p53 (pS315) Antibody
abx012304-100ug	Abbexa	100 ug
p53 (pS20) Antibody
abx031895-400ul	Abbexa	400 ul
p53 (pS20) Antibody
abx031895-80l	Abbexa	80 µl
p53 (pS315) Antibody
abx031896-400ul	Abbexa	400 ul
p53 (pS315) Antibody
abx031896-80l	Abbexa	80 µl
P53 (pS9) Antibody
abx031898-400ul	Abbexa	400 ul
P53 (pS9) Antibody
abx031898-80l	Abbexa	80 µl
p53 (pT18) Antibody
abx031899-400ul	Abbexa	400 ul
p53 (pT18) Antibody
abx031899-80l	Abbexa	80 µl
p53 (pT55) Antibody
abx032008-400ul	Abbexa	400 ul
p53 (pT55) Antibody
abx032008-80l	Abbexa	80 µl
p53 Blocking Peptide
20-abx061761	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx061762	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx061786	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx061860	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx061862	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx061873	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx063380	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx063381	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx063383	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx063384	Abbexa	1 mg 5 mg
p53 Blocking Peptide
20-abx063385	Abbexa	1 mg 5 mg
p53 Mutant Protein
20-abx263550	Abbexa	10 ug 2 µg 5 ug
P53 recombinant protein
E62C02301	EnoGene	20ug
P53 Polyclonal Antibody
EA173-100ul	ELK Biotech	100ul
P53 Polyclonal Antibody
EA173-50ul	ELK Biotech	50ul
Anti-p53 Antibody
CI1060	BosterBio	50ug/50ul
p53 Blocking Peptide
AF0865-BP	Affbiotech	1mg
p53 Blocking Peptide
AF0877-BP	Affbiotech	1mg
p53 Blocking Peptide
AF0879-BP	Affbiotech	1mg
p53 Blocking Peptide
AF4663-BP	Affbiotech	1mg
p53 Blocking Peptide
AF4664-BP	Affbiotech	1mg
p53 Blocking Peptide
AF6073-BP	Affbiotech	1mg
p53 Blocking Peptide
AF6074-BP	Affbiotech	1mg
P53 Blocking Peptide
AF6078-BP	Affbiotech	1mg
p53(PAb122) Antibody
BNUB0338-100	Biotium	100uL
p53(PAb122) Antibody
BNUB0338-500	Biotium	500uL
p53(PAb122) Antibody
BNUM0338-50	Biotium	50uL
p53 Blocking Peptide
BF0604-BP	Affbiotech	1mg
p53 Mouse mAb
BF9304	Lifescience Market	100 ug
p53(PAb122) Antibody
BNC040338-100	Biotium	100uL
p53(PAb122) Antibody
BNC040338-500	Biotium	500uL
p53(PAb122) Antibody
BNC610338-100	Biotium	100uL
p53(PAb122) Antibody
BNC610338-500	Biotium	500uL
p53(PAb122) Antibody
BNC470338-100	Biotium	100uL
p53(PAb122) Antibody
BNC470338-500	Biotium	500uL
p53(PAb122) Antibody
BNC550338-100	Biotium	100uL
p53(PAb122) Antibody
BNC550338-500	Biotium	500uL
p53(PAb122) Antibody
BNC050338-100	Biotium	100uL
p53(PAb122) Antibody
BNC050338-500	Biotium	500uL
p53(PAb122) Antibody
BNC400338-100	Biotium	100uL
p53(PAb122) Antibody
BNC400338-500	Biotium	500uL
p53(PAb122) Antibody
BNC430338-100	Biotium	100uL
p53(PAb122) Antibody
BNC430338-500	Biotium	500uL
p53 Antibody (Biotin)
abx446375-100ug	Abbexa	100 ug
p53 Antibody (FITC)
abx446376-100ug	Abbexa	100 ug
p53 Antibody (HRP)
abx446377-100ug	Abbexa	100 ug
p53(PAb122) Antibody
BNC800338-100	Biotium	100uL
p53(PAb122) Antibody
BNC800338-500	Biotium	500uL
p53(PAb122) Antibody
BNC810338-100	Biotium	100uL
p53(PAb122) Antibody
BNC810338-500	Biotium	500uL
p53(PAb122) Antibody
BNCP0338-250	Biotium	250uL
p53(PAb122) Antibody
BNCR0338-250	Biotium	250uL
p53(PAb122) Antibody
BNCA0338-250	Biotium	250uL
p53(PAb122) Antibody
BNCAP0338-100	Biotium	100uL
p53(PAb122) Antibody
BNCAP0338-500	Biotium	500uL
p53(PAb122) Antibody
BNCH0338-100	Biotium	100uL
p53(PAb122) Antibody
BNCH0338-500	Biotium	500uL
p53(PAb122) Antibody
BNC940338-100	Biotium	100uL
p53(PAb122) Antibody
BNC940338-500	Biotium	500uL
p53(PAb122) Antibody
BNC700338-100	Biotium	100uL
p53(PAb122) Antibody
BNC700338-500	Biotium	500uL
p53(PAb122) Antibody
BNCB0338-100	Biotium	100uL
p53(PAb122) Antibody
BNCB0338-500	Biotium	500uL
p53(PAb122) Antibody
BNC880338-100	Biotium	100uL
p53(PAb122) Antibody
BNC880338-500	Biotium	500uL
p53(PAb122) Antibody
BNC680338-100	Biotium	100uL
p53(PAb122) Antibody
BNC680338-500	Biotium	500uL
p53 Blocking Peptide
AF7685-BP	Affbiotech	1mg
p53 Blocking Peptide
AF7686-BP	Affbiotech	1mg
p53 Polyclonal Antibody
ABP53071-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP53071-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP53071-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP53072-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP53072-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP53072-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP53235-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP53235-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP53235-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP53236-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP53236-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP53236-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP53237-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP53237-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP53237-02ml	Abbkine	0.2ml
p53 Monoclonal Antibody
ABM40052-003ml	Abbkine	0.03ml
p53 Monoclonal Antibody
ABM40052-01ml	Abbkine	0.1ml
p53 Monoclonal Antibody
ABM40052-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP52117-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP52117-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP52117-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP52118-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP52118-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP52118-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP52119-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP52119-01ml	Abbkine	0.1ml
p53 Polyclonal Antibody
ABP52119-02ml	Abbkine	0.2ml
p53 Polyclonal Antibody
ABP52120-003ml	Abbkine	0.03ml
p53 Polyclonal Antibody
ABP52120-01ml	Abbkine	0.1ml

p53-dependent transcription

Among the key signs of the study is that inhibitors of the p53-dependent transcriptional action (pifithrin-α, E6 protein overexpression, or p53 dominant adverse gene expression) blocked PM-induced mitochondrial dysfunction, as assessed by Δψm along with caspase-9 activation, also as apoptosis, as evaluated by annexin V staining and DNA fragmentation.

Furthermore, the protecting effects reported in A549-E6 cells exposed to PM from the current study are like the effects observed from radiation- related and asbestos-induced cytotoxicity .

The p53 tumor suppressor protein has been also well known for its job as a transcription factor which modulates the expression of stress response genes and mediates quite a few anti-proliferative processes.

• Underscoring its importance at the regulation of proliferative homeostasis, it is the most frequently mutated tumor suppressor in human cancers.
• It’s known to mediate its effects through the activation of genes regulating cell cycle checkpoints, DNA damage and repair, and apoptosis.
• For apoptosis specifically, p53 enriches the manifestation Bcl-2 relatives like Bax, BID, PUMA, along with Noxa.3-6 It’s also known to regulate APAF-1, a coactivator of this apoptosis initiator Caspase-9.
• Though its position for a mediator of transcription is well recognized, some studies seem to suggest that p53 could affect apoptosis by means of publication transcription-independent pathways.

Spots of low/insufficient oxygen (hypoxia) really are a pathophysiological characteristic of most solid tumors (inch ).

It has been demonstrated conclusively that people using significant heights of tumor hypoxia possess a worse prognosis regardless of therapy modality (2 – 4). Within a tumor, gradients of oxygen levels exist, which are likely to accomplish whole anoxia in avascular are as.

Cells exposed to severe hypoxia are involved in Aopotosis.